The short answer
On paper these two Levoit purifiers clean the same amount of air. The Vital 100S is rated at 143 cfm and the Core 300S at 141 cfm, so neither handles a bigger room. Choose by shape and features:
- Core 300S: lighter, uses less power, and offers more replacement-filter types.
- Vital 100S: adds a washable pre-filter, a Pet Mode and a slim rectangular body that sits closer to a wall.
Specs side by side
Figures come from Levoit’s current product pages, which list the “-P” versions of both models. They were checked October 3, 2026. Older units can differ slightly, mainly in power draw.
| Spec | Vital 100S | Core 300S |
|---|---|---|
| CADR | 143 cfm | 141 cfm |
| Room size at 4.8 air changes/hour | 222 sq. ft. | 219 sq. ft. |
| Room size at 1 air change/hour | 1,066 sq. ft. | 1,051 sq. ft. |
| Sound level | 23–52 dB | 22–50 dB |
| Rated power | 35 W | 23 W |
| Size | 12.6 × 6.3 × 16.0 in. | 8.7 × 8.7 × 14.2 in. (round) |
| Weight | 8.6 lb | 5.95 lb |
| Filtration | 3-stage, washable pre-filter | 3-stage |
| Air quality sensor | Infrared dust sensor | AirSight Plus sensor |
| Modes | Auto, Sleep, Pet | Auto, Sleep |
| App and voice | VeSync, Alexa, Google Assistant | VeSync, Alexa, Google Assistant |
Room size: the number that matters
Use the 4.8 air changes per hour figure, about 220 sq. ft. for both models. That is the room size the Association of Home Appliance Manufacturers uses for its ratings, and it is the right target for allergies, pets and smoke. Levoit’s 1,000-plus sq. ft. figure assumes the air is cleaned only once an hour.
In practice, both fit a bedroom, nursery or home office. Neither suits an open living area, and buying the Vital 100S instead of the Core 300S doesn’t change that.
Where they differ
Shape and placement. The Vital 100S is a flat, rectangular unit only 6.3 inches deep, with an intake across the front and sides. The Core 300S is a cylinder that draws air all the way around. Their floor footprints are similar. The Vital 100S fits better along a wall or beside a nightstand, while the Core 300S fits better in a corner that leaves clearance on every side.
Weight and power. The Core 300S is about 2.7 lb lighter and draws 23 W against 35 W at top speed. Run around the clock at full speed, that works out to roughly 200 kWh versus 307 kWh a year. Real use on auto is usually much lower.
Pets. The Vital 100S has a Pet Mode and a washable pre-filter you can rinse when it fills with fur, which can extend the life of the main filter. Levoit says its U-shaped inlet is designed to catch pet hair. The Core 300S doesn’t list a separate washable pre-filter, but it offers a Pet Allergy replacement filter.
Filter choice. The Core 300S filter comes in Original, Toxin Absorber, Pet Allergy and Smoke Remover versions. That’s useful if you want extra carbon for cooking or smoke odor. Check that the part number matches your exact model before you buy filters.
Which to buy
- Pick the Core 300S for a small bedroom or office if you want the lighter, lower-power unit, or a smoke or odor filter.
- Pick the Vital 100S for a room with a shedding pet, or one where the purifier has to sit flat against a wall.
- Pick neither if the room is much larger than about 220 sq. ft. Both are rated for the same capacity, so you need a larger model.
Frequently Asked Questions
Does the Vital 100S clean a bigger room than the Core 300S?
No. Levoit rates the Vital 100S at 143 cfm and 222 sq. ft. and the Core 300S at 141 cfm and 219 sq. ft., both at 4.8 air changes per hour. That difference is too small to matter.
Which one is quieter?
They are within a couple of decibels. Levoit lists 23–52 dB for the Vital 100S and 22–50 dB for the Core 300S.
Which one is better for pets?
The Vital 100S has a Pet Mode, a washable pre-filter and a wide U-shaped inlet that Levoit says helps catch pet fur. The Core 300S offers a Pet Allergy replacement filter instead. Both deliver the same clean air.
What size room are they for?
About 220 sq. ft. for allergy or smoke use. Levoit’s 1,000-plus sq. ft. figures assume only one air change per hour, which is too slow for most purposes. For a larger room, step up to a bigger purifier.
Sources
See Also
If you are still weighing both sides of this matchup, keep going with Blueair 211i Max vs. 311i Max: Which Air Purifier Should You Choose?, Levoit Core 600S Smart Air Purifier Review: Pros, Cons, and Verdict, and Winix 5510 Review: Room Size, Filter Q and the Cost of App Control.
To widen the decision beyond this head-to-head, Best Air Purifiers for Cigarette Smoke in 2026 and Best Air Purifiers for Wildfire Smoke in 2026 provide the broader context.